감응유전

1 개요

telegony
感應遺傳, 先父遺傳
감응유전, 선부유전

자식이 어미의 이전 교미 상대의 특성을 물려받는 현상^[1]

아우구스트 바이스만이 이름 붙이고 진화론의 찰스 다윈 등이 유전현상(heredity)의 기전(mechanism)을 밝히기 위해 특별히 중시한 감응유전은 암컷의 이전 교미 상대가 그 암컷에 남긴 영향을 통해 다음 교미 상대와의 자식에까지 영향을 끼치는 현상, 즉 자식이 어미의 이전 교미 상대의 특성을 물려받는 현상을 의미한다. 재현실험에 실패하고 멘델의 유전법칙과 발견된 유전물질로 기전을 설명할 수 없었기 때문에 반증되었다 여겨졌으나, 후성유전학의 등장으로 이론적으로 설명할 수 있는 여러 기전들이 제안되었고, 좀파리^[2], 송장벌레^[3] 등을 이용한 통제된 실험을 통해 실존하는 현상임이 입증되었다.

2 이론적으로 설명 가능한 기전과 뒷받침하는 실험들

2.1 암컷의 생식기관 체세포조직 안으로 침투하는 정자와 형질전환^[4]

2.2 체세포 안으로 혼입되는 외인성 DNA^[5]

2.3 어미 혈액에 흐르는 태아 유전자의 역할^[6]

3 사례와 근거

3.1 통제된 실험으로 입증

자식의 크기가 생물학적 아버지가 아닌 어미의 이전 교미 상대의 영향을 받은 좀파리와 송장벌레.

호주의 긴잎아카시아에 서식하는 좀파리^[2]의 의 경우 자식의 몸 크기가 생물학적 아버지가 아닌 어미의 이전 교미 상대의 몸 크기와 닮게 되는 현상을 보였다.

검정수염송장벌레^[3]의 경우 이전 교미 상대가 암컷의 가임력에 미치는 영향을 통해 다음 교미 상대와 낳은 새끼의 크기에 영향을 미치는 것을 보였다.

3.2 사례 보고^[7]

사례 보고 논문 목록
1. 말(Douglas, 1821; Finn, 1893)
2. 돼지 (Giles, 1815; Lowe, 1896)
3. 개 (Cornevin, 1891; Darwin and Murray, 1868)
4. 고양이 (Lowe, 1896)
5. 양 (Darwin and Murray, 1868; Finn, 1893)
6. 쥐 (Gorczynski et al., 1983)
7. 토끼 (Parer et al., 1995; Sobey and Conolly, 1986; Williams and Moore, 1991; Zhelnin, 1964)
8. 인간 (Cornevin, 1891; Flint, 1877; Lingard, 1884; Lowe, 1896; Webber, 1896)

4 주석

↑ ^1.0 ^1.1 Telegony refers to the appearance of some characteristics of the female's previously mated male in her subsequent offspring by another male, https://doi.org/10.1016/j.pbiomolbio.2022.07.002
↑ ^2.0 ^2.1 ^2.2 Crean, Angela J.; Kopps, Anna M.; Bonduriansky, Russell (2014). “Revisiting telegony: offspring inherit an acquired characteristic of their mother's previous mate”. 《Ecology Letters》 (영어) 17 (12): 1545–1552. doi:10.1111/ele.12373. ISSN 1461-0248. PMC 4282758. PMID 25270393.
↑ ^3.0 ^3.1 ^3.2 Pascoal, S; Jarrett, BJM; Evans, E; Kilner, RM (2014). “Superior stimulation of female fecundity by subordinate males provides a mechanism for telegony”. 《Evolution Letters》 (영어) 2 (2): 114–125. doi:10.1002/evl3.45. PMC 6121788. PMID 30283669.
↑ ^4.0 ^4.1
논문 목록
- Kohlbrugge, J., 1910. Der Einfluß der Spermatozoiden auf den Uterus. Z. Morphol. Anthropol. 19–30.
- Kohlbrugge, J.H.F., 1912. Die Verbreitung der Spermatozoïden im weiblicher Korper ¨ und im befruchteten Ei. Wilhelm Engelmann.
- Austin, C., 1959. Entry of spermatozoa into the fallopian-tube mucosa. Nature 183, 908–909.
- Austin, C., 1960. Fate of spermatozoa in the female genital tract. Reproduction 1, 151.
- Austin, C., Bishop, M., 1959. Presence of spermatozoa in the uterine-tube mucosa of bats. In: Book Presence of Spermatozoa in the Uterine-Tube Mucosa of Bats. SOC ENDOCRINOLOGY 17/18 the COURTYARD, WOODLANDS, BRADLEY STOKE. BRISTOL ..., City, pp. R8–R9.
- Bendich, A., Borenfreund, E., Sternberg, S.S., 1974. Penetration of somatic mammalian cells by sperm. Science 183, 857–859.
- Brodsky, S.V., Ivanov, I., 2009. Spermatozoa-somatic cell fusion-A mechanism for microchimerism formation. J. Theor. Biol. 259, 190–192.
↑ ^5.0 ^5.1
논문 목록
- Bendich, A., Borenfreund, E., Sternberg, S.S., 1974. Penetration of somatic mammalian cells by sperm. Science 183, 857–859.
- Ledoux, L., Charles, P., 1972. Fate of Exogenous DNA in Mammals, Uptake of Informative Molecules by Living Cells, pp. 397–413.
- Watson, J.G., Carroll, J., Chaykin, S., 1983. Reproduction in mice: the fate of spermatozoa not involved in fertilization. Gamete Res. 7, 75–84.
- Wolff, J.A., Malone, R.W., Williams, P., Chong, W., Acsadi, G., Jani, A., Felgner, P.L., 1990. Direct gene transfer into mouse muscle in vivo. Science 247, 1465–1468.
- Holmgren, L., Szeles, A., Rajnavolgyi, ¨ E., Folkman, J., Klein, G., Ernberg, I., Falk, K.I., 1999. Horizontal transfer of DNA by the uptake of apoptotic bodies, Blood. J. Am. Soc. Hematol. 93, 3956–3963.
↑ ^6.0 ^6.1
논문 목록
- Lo, Y.D., Corbetta, N., Chamberlain, P.F., Rai, V., Sargent, I.L., Redman, C.W., Wainscoat, J.S., 1997. Presence of fetal DNA in maternal plasma and serum. The lancet 350, 485–487.
- Lo, Y.D., Tein, M.S., Lau, T.K., Haines, C.J., Leung, T.N., Poon, P.M., Wainscoat, J.S., Johnson, P.J., Chang, A.M., Hjelm, N.M., 1998. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am. J. Hum. Genet. 62, 768–775.
- Tsui, N.B.Y., Lo, Y.M.D., 2012. Recent advances in the analysis of fetal nucleic acids in maternal plasma. Curr. Opin. Hematol. 19, 462–468.
- Bianchi, D.W., Zickwolf, G.K., Weil, G.J., Sylvester, S., DeMaria, M.A., 1996. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc. Natl. Acad. Sci. USA 93, 705–708.
- Invernizzi, P., Biondi, M., Battezzati, P., Perego, F., Selmi, C., Cecchini, F., Podda, M., Simoni, G., 2002. Presence of fetal DNA in maternal plasma decades after pregnancy. Hum. Genet. 110, 587–591.
- Lissauer, D., Piper, K., Moss, P., Kilby, M., 2007. Persistence of fetal cells in the mother: friend or foe? BJOG An Int. J. Obstet. Gynaecol. 114, 1321–1325.
- Fan, H.C., Gu, W., Wang, J., Blumenfeld, Y.J., El-Sayed, Y.Y., Quake, S.R., 2012. Noninvasive prenatal measurement of the fetal genome. Nature 487, 320–324.
↑ ^7.0 ^7.1
논문 목록
- Douglas, G., 1821. III. A Communication of a Singular Fact in Natural History. By the Right Honourable the Earl of Morton, FRS in a Letter Addressed to the President. Philosophical Transactions of the Royal Society of London, pp. 20–22.
- Finn, F., 1893. Some facts of telegony. Nat. Sci. 3, 436–446.
- Giles, D., 1815. Particulars of a fact, nearly similar to that related by lord morton, communicated to the president. In: In a Letter from Daniel Giles, Esq, Proceedings of the Royal Society of London Series I., vol. 2, p. 137.
- Lowe, E., 1896. Telegony. Br. Med. J. 2, 1352.
- Cornevin, C., 1891. Trait´e de zootechnie g´en´erale. JB Bailli`ere.
- Darwin, C., Murray, J., 1868. The Variation of Animals and Plants under Domestication Edit.
- Gorczynski, R., Kennedy, M., MacRae, S., Ciampi, A., 1983. A possible maternal effect in the abnormal hyporesponsiveness to specific alloantigens in offspring born to neonatally tolerant fathers. J. Immunol. 131, 1115–1120.
- Parer, I., Sobey, W., Conolly, D., Morton, R., 1995. Sire transmission of acquiredresistance to Myxomatosis. Aust. J. Zool. 43, 459–465.
- Sobey, W., Conolly, D., 1986. Myxomatosis-nongenetic aspects of resistance to myxomatosis in rabbits, oryctolagus-cuniculus. Wildl. Res. 13, 177–187.
- Williams, C.K., Moore, R., 1991. Inheritance of acquired-immunity to myxomatosis. Aust. J. Zool. 39, 307–311.
- Zhelnin, V., 1964. The phenomenon of telegony in rabbits. Krolikovodstvo Zvehovodstvo 7, 20–21.
- Flint, A., 1877. A Text-Book of Human Physiology. D. Appleton and company.
- Lingard, A., 1884. The hereditary transmission of hypospadias and its transmission by indirect Atavism. Lancet 123, 703.
- Webber, H., 1896. Telegony, bmj. Br. Med. J. 2, 1083.

5 참고문헌

Liu, YS (April 2011). “Telegony, the Sire Effect and non-Mendelian Inheritance Mediated by Spermatozoa: A Historical Overview and Modern Mechanistic Speculations”. 《Reproduction in Domestic Animals》 46 (2): 338–343. doi:10.1111/j.1439-0531.2010.01672.x. PMID 20626678.
Liu, YS (Jul 20, 2018). 〈Darwin’s Pangenesis and Certain Anomalous Phenomena〉. Dhavendra, Kumar. 《Darwin’s Pangenesis and Its Rediscovery Part B, Advances in Genetics 102》. ISBN 9780128151297.
Nejabati, HR; Roshangar, L; Nouri, M (Jul 2022). “Uterosomes: The lost ring of telegony?”. 《Progress in Biophysics and Molecular Biology》 174: 55–61. doi:10.1016/j.pbiomolbio.2022.07.002. PMID 35843387.

6 같이 보기

7 참고

[def-1] 1.0 ^1.1 Telegony refers to the appearance of some characteristics of the female's previously mated male in her subsequent offspring by another male, https://doi.org/10.1016/j.pbiomolbio.2022.07.002

[fly-2] 2.0 ^2.1 ^2.2 Crean, Angela J.; Kopps, Anna M.; Bonduriansky, Russell (2014). “Revisiting telegony: offspring inherit an acquired characteristic of their mother's previous mate”. 《Ecology Letters》 (영어) 17 (12): 1545–1552. doi:10.1111/ele.12373. ISSN 1461-0248. PMC 4282758. PMID 25270393.

[beetle-3] 3.0 ^3.1 ^3.2 Pascoal, S; Jarrett, BJM; Evans, E; Kilner, RM (2014). “Superior stimulation of female fecundity by subordinate males provides a mechanism for telegony”. 《Evolution Letters》 (영어) 2 (2): 114–125. doi:10.1002/evl3.45. PMC 6121788. PMID 30283669.

[2.1-4] 4.0 ^4.1 논문 목록
Kohlbrugge, J., 1910. Der Einfluß der Spermatozoiden auf den Uterus. Z. Morphol. Anthropol. 19–30.

Kohlbrugge, J.H.F., 1912. Die Verbreitung der Spermatozoïden im weiblicher Korper ¨ und im befruchteten Ei. Wilhelm Engelmann.

Austin, C., 1959. Entry of spermatozoa into the fallopian-tube mucosa. Nature 183, 908–909.

Austin, C., 1960. Fate of spermatozoa in the female genital tract. Reproduction 1, 151.

Austin, C., Bishop, M., 1959. Presence of spermatozoa in the uterine-tube mucosa of bats. In: Book Presence of Spermatozoa in the Uterine-Tube Mucosa of Bats. SOC ENDOCRINOLOGY 17/18 the COURTYARD, WOODLANDS, BRADLEY STOKE. BRISTOL ..., City, pp. R8–R9.

Bendich, A., Borenfreund, E., Sternberg, S.S., 1974. Penetration of somatic mammalian cells by sperm. Science 183, 857–859.

Brodsky, S.V., Ivanov, I., 2009. Spermatozoa-somatic cell fusion-A mechanism for microchimerism formation. J. Theor. Biol. 259, 190–192.

[5] Kohlbrugge, J., 1910. Der Einfluß der Spermatozoiden auf den Uterus. Z. Morphol. Anthropol. 19–30.

[6] Kohlbrugge, J.H.F., 1912. Die Verbreitung der Spermatozoïden im weiblicher Korper ¨ und im befruchteten Ei. Wilhelm Engelmann.

[7] Austin, C., 1959. Entry of spermatozoa into the fallopian-tube mucosa. Nature 183, 908–909.

[8] Austin, C., 1960. Fate of spermatozoa in the female genital tract. Reproduction 1, 151.

[9] Austin, C., Bishop, M., 1959. Presence of spermatozoa in the uterine-tube mucosa of bats. In: Book Presence of Spermatozoa in the Uterine-Tube Mucosa of Bats. SOC ENDOCRINOLOGY 17/18 the COURTYARD, WOODLANDS, BRADLEY STOKE. BRISTOL ..., City, pp. R8–R9.

[10] Bendich, A., Borenfreund, E., Sternberg, S.S., 1974. Penetration of somatic mammalian cells by sperm. Science 183, 857–859.

[11] Brodsky, S.V., Ivanov, I., 2009. Spermatozoa-somatic cell fusion-A mechanism for microchimerism formation. J. Theor. Biol. 259, 190–192.

[2.2-5] 5.0 ^5.1 논문 목록
Bendich, A., Borenfreund, E., Sternberg, S.S., 1974. Penetration of somatic mammalian cells by sperm. Science 183, 857–859.

Ledoux, L., Charles, P., 1972. Fate of Exogenous DNA in Mammals, Uptake of Informative Molecules by Living Cells, pp. 397–413.

Watson, J.G., Carroll, J., Chaykin, S., 1983. Reproduction in mice: the fate of spermatozoa not involved in fertilization. Gamete Res. 7, 75–84.

Wolff, J.A., Malone, R.W., Williams, P., Chong, W., Acsadi, G., Jani, A., Felgner, P.L., 1990. Direct gene transfer into mouse muscle in vivo. Science 247, 1465–1468.

Holmgren, L., Szeles, A., Rajnavolgyi, ¨ E., Folkman, J., Klein, G., Ernberg, I., Falk, K.I., 1999. Horizontal transfer of DNA by the uptake of apoptotic bodies, Blood. J. Am. Soc. Hematol. 93, 3956–3963.

[13] Bendich, A., Borenfreund, E., Sternberg, S.S., 1974. Penetration of somatic mammalian cells by sperm. Science 183, 857–859.

[14] Ledoux, L., Charles, P., 1972. Fate of Exogenous DNA in Mammals, Uptake of Informative Molecules by Living Cells, pp. 397–413.

[15] Watson, J.G., Carroll, J., Chaykin, S., 1983. Reproduction in mice: the fate of spermatozoa not involved in fertilization. Gamete Res. 7, 75–84.

[16] Wolff, J.A., Malone, R.W., Williams, P., Chong, W., Acsadi, G., Jani, A., Felgner, P.L., 1990. Direct gene transfer into mouse muscle in vivo. Science 247, 1465–1468.

[17] Holmgren, L., Szeles, A., Rajnavolgyi, ¨ E., Folkman, J., Klein, G., Ernberg, I., Falk, K.I., 1999. Horizontal transfer of DNA by the uptake of apoptotic bodies, Blood. J. Am. Soc. Hematol. 93, 3956–3963.

[2.3-6] 6.0 ^6.1 논문 목록
Lo, Y.D., Corbetta, N., Chamberlain, P.F., Rai, V., Sargent, I.L., Redman, C.W., Wainscoat, J.S., 1997. Presence of fetal DNA in maternal plasma and serum. The lancet 350, 485–487.

Lo, Y.D., Tein, M.S., Lau, T.K., Haines, C.J., Leung, T.N., Poon, P.M., Wainscoat, J.S., Johnson, P.J., Chang, A.M., Hjelm, N.M., 1998. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am. J. Hum. Genet. 62, 768–775.

Tsui, N.B.Y., Lo, Y.M.D., 2012. Recent advances in the analysis of fetal nucleic acids in maternal plasma. Curr. Opin. Hematol. 19, 462–468.

Bianchi, D.W., Zickwolf, G.K., Weil, G.J., Sylvester, S., DeMaria, M.A., 1996. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc. Natl. Acad. Sci. USA 93, 705–708.

Invernizzi, P., Biondi, M., Battezzati, P., Perego, F., Selmi, C., Cecchini, F., Podda, M., Simoni, G., 2002. Presence of fetal DNA in maternal plasma decades after pregnancy. Hum. Genet. 110, 587–591.

Lissauer, D., Piper, K., Moss, P., Kilby, M., 2007. Persistence of fetal cells in the mother: friend or foe? BJOG An Int. J. Obstet. Gynaecol. 114, 1321–1325.

Fan, H.C., Gu, W., Wang, J., Blumenfeld, Y.J., El-Sayed, Y.Y., Quake, S.R., 2012. Noninvasive prenatal measurement of the fetal genome. Nature 487, 320–324.

[19] Lo, Y.D., Corbetta, N., Chamberlain, P.F., Rai, V., Sargent, I.L., Redman, C.W., Wainscoat, J.S., 1997. Presence of fetal DNA in maternal plasma and serum. The lancet 350, 485–487.

[20] Lo, Y.D., Tein, M.S., Lau, T.K., Haines, C.J., Leung, T.N., Poon, P.M., Wainscoat, J.S., Johnson, P.J., Chang, A.M., Hjelm, N.M., 1998. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am. J. Hum. Genet. 62, 768–775.

[21] Tsui, N.B.Y., Lo, Y.M.D., 2012. Recent advances in the analysis of fetal nucleic acids in maternal plasma. Curr. Opin. Hematol. 19, 462–468.

[22] Bianchi, D.W., Zickwolf, G.K., Weil, G.J., Sylvester, S., DeMaria, M.A., 1996. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc. Natl. Acad. Sci. USA 93, 705–708.

[23] Invernizzi, P., Biondi, M., Battezzati, P., Perego, F., Selmi, C., Cecchini, F., Podda, M., Simoni, G., 2002. Presence of fetal DNA in maternal plasma decades after pregnancy. Hum. Genet. 110, 587–591.

[24] Lissauer, D., Piper, K., Moss, P., Kilby, M., 2007. Persistence of fetal cells in the mother: friend or foe? BJOG An Int. J. Obstet. Gynaecol. 114, 1321–1325.

[25] Fan, H.C., Gu, W., Wang, J., Blumenfeld, Y.J., El-Sayed, Y.Y., Quake, S.R., 2012. Noninvasive prenatal measurement of the fetal genome. Nature 487, 320–324.

[cases-7] 7.0 ^7.1 논문 목록
Douglas, G., 1821. III. A Communication of a Singular Fact in Natural History. By the Right Honourable the Earl of Morton, FRS in a Letter Addressed to the President. Philosophical Transactions of the Royal Society of London, pp. 20–22.

Finn, F., 1893. Some facts of telegony. Nat. Sci. 3, 436–446.

Giles, D., 1815. Particulars of a fact, nearly similar to that related by lord morton, communicated to the president. In: In a Letter from Daniel Giles, Esq, Proceedings of the Royal Society of London Series I., vol. 2, p. 137.

Lowe, E., 1896. Telegony. Br. Med. J. 2, 1352.

Cornevin, C., 1891. Trait´e de zootechnie g´en´erale. JB Bailli`ere.

Darwin, C., Murray, J., 1868. The Variation of Animals and Plants under Domestication Edit.

Gorczynski, R., Kennedy, M., MacRae, S., Ciampi, A., 1983. A possible maternal effect in the abnormal hyporesponsiveness to specific alloantigens in offspring born to neonatally tolerant fathers. J. Immunol. 131, 1115–1120.

Parer, I., Sobey, W., Conolly, D., Morton, R., 1995. Sire transmission of acquiredresistance to Myxomatosis. Aust. J. Zool. 43, 459–465.

Sobey, W., Conolly, D., 1986. Myxomatosis-nongenetic aspects of resistance to myxomatosis in rabbits, oryctolagus-cuniculus. Wildl. Res. 13, 177–187.

Williams, C.K., Moore, R., 1991. Inheritance of acquired-immunity to myxomatosis. Aust. J. Zool. 39, 307–311.

Zhelnin, V., 1964. The phenomenon of telegony in rabbits. Krolikovodstvo Zvehovodstvo 7, 20–21.

Flint, A., 1877. A Text-Book of Human Physiology. D. Appleton and company.

Lingard, A., 1884. The hereditary transmission of hypospadias and its transmission by indirect Atavism. Lancet 123, 703.

Webber, H., 1896. Telegony, bmj. Br. Med. J. 2, 1083.

[27] Douglas, G., 1821. III. A Communication of a Singular Fact in Natural History. By the Right Honourable the Earl of Morton, FRS in a Letter Addressed to the President. Philosophical Transactions of the Royal Society of London, pp. 20–22.

[28] Finn, F., 1893. Some facts of telegony. Nat. Sci. 3, 436–446.

[29] Giles, D., 1815. Particulars of a fact, nearly similar to that related by lord morton, communicated to the president. In: In a Letter from Daniel Giles, Esq, Proceedings of the Royal Society of London Series I., vol. 2, p. 137.

[30] Lowe, E., 1896. Telegony. Br. Med. J. 2, 1352.

[31] Cornevin, C., 1891. Trait´e de zootechnie g´en´erale. JB Bailli`ere.

[32] Darwin, C., Murray, J., 1868. The Variation of Animals and Plants under Domestication Edit.

[33] Gorczynski, R., Kennedy, M., MacRae, S., Ciampi, A., 1983. A possible maternal effect in the abnormal hyporesponsiveness to specific alloantigens in offspring born to neonatally tolerant fathers. J. Immunol. 131, 1115–1120.

[34] Parer, I., Sobey, W., Conolly, D., Morton, R., 1995. Sire transmission of acquiredresistance to Myxomatosis. Aust. J. Zool. 43, 459–465.

[35] Sobey, W., Conolly, D., 1986. Myxomatosis-nongenetic aspects of resistance to myxomatosis in rabbits, oryctolagus-cuniculus. Wildl. Res. 13, 177–187.

[36] Williams, C.K., Moore, R., 1991. Inheritance of acquired-immunity to myxomatosis. Aust. J. Zool. 39, 307–311.

[37] Zhelnin, V., 1964. The phenomenon of telegony in rabbits. Krolikovodstvo Zvehovodstvo 7, 20–21.

[38] Flint, A., 1877. A Text-Book of Human Physiology. D. Appleton and company.

[39] Lingard, A., 1884. The hereditary transmission of hypospadias and its transmission by indirect Atavism. Lancet 123, 703.

[40] Webber, H., 1896. Telegony, bmj. Br. Med. J. 2, 1083.

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